Dresden 2020 – wissenschaftliches Programm

Die DPG-Frühjahrstagung in Dresden musste abgesagt werden! Lesen Sie mehr ...

Bereiche | Tage | Auswahl | Suche | Aktualisierungen | Downloads | Hilfe

BP: Fachverband Biologische Physik

BP 18: Poster VI

BP 18.12: Poster

Dienstag, 17. März 2020, 14:00–16:00, P2/2OG

Parameter Optimization of a Cellular Potts Model using Multiple Micro-Pattern Cell Migration Experiments — •Sophia Anna Schaffer1, Andriy Goychuk2, Christoph Schreiber1, Erwin Frey2, and Joachim Rädler11Fakultät für Physik, Ludwig-Maximilians-Universität, Geschwister-Scholl-Platz 1, 80539 München — 2Arnold Sommerfeld Center, Ludwig-Maximilians-Universität, Theresienstraße 37, 80333 München

Modelling cell migration is important to simplify and understand the highly complex machinery of cells. Cellular Potts Models (CPMs) have been successfully used to reproduce cell migration patterns in two dimensions. They are capable to reproduce cell behavior with increasing levels of complexity and biological accuracy from single cells to collective migration. A particular challenge for computational simulations is to optimize model assumptions and parameters so that many experimental data sets are fitted simultaneously. Cells in confining geometries show restricted motion and various properties of cell behavior such as deformation, persistence, adhesion and polarization can be separately probed. Here, we still present a rational approach to use a set of geometries with complementary properties to determine parameter values successively in a systematic manner using one specific cell line. The general concept is to determine model parameters successively by using the emergent properties of the different geometry designs.

100% | Mobil-Ansicht | English Version | Kontakt/Impressum/Datenschutz
DPG-Physik > DPG-Verhandlungen > 2020 > Dresden