Dresden 2020 – wissenschaftliches Programm

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BP: Fachverband Biologische Physik

BP 18: Poster VI

BP 18.22: Poster

Dienstag, 17. März 2020, 14:00–16:00, P2/2OG

Engineering motile amoeboid cells toward precise and targeted microtransport — •Setareh Sharifi Panah1, Oliver Nagel1, Valentino Lepro1,2, Robert Grossmann1, and Carsten Beta11Institute of Physics and Astronomy, University of Potsdam, 14476 Potsdam, Germany — 2Max Planck Institute of Colloids and Interfaces, 14476 Potsdam, Germany

Over the past decades, growing efforts have been invested on bio-hybrid microsystems. However, applications such as targeted drug delivery through complex environments remain challenging. Inspired by leukocytes, we propose to exploit the potential of eukaryotic cells for microtransport, using the Dictyostelium discoideum cells as model. Our experiments highlight the ability of amoeboid cells to displace cargo particles with faster spreading cargo-loaded cells, suggesting cell-particle interactions as a stimulus promoting cell motility. Further, we developed a physical model which captures the main motility aspects of our system. Chemotaxis experiments reveal a guided transport driven by both single and collective cells. Remarkably, active microtransport across 3D collagen matrices suggest reliability of our system also in complex environments. To get an insight into the cell-particle dynamis, the approximate pulling force exerted on a cargo by the cell, is being estimated using microfluidics. Interestingly, under constant drag force of up to a few nano Newton, agent cells maintain their adhesion site to the cargo while being pulled downstream, suggesting limited yet considerable applied force to the cargo. These findings serve as a basis for undestanding underlying mechanics of such microtransport.

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