Dresden 2020 – wissenschaftliches Programm

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BP: Fachverband Biologische Physik

BP 18: Poster VI

BP 18.3: Poster

Dienstag, 17. März 2020, 14:00–16:00, P2/2OG

Network adaptation to transient stroke — •Leonie Bastin1, Komal Bhattacharyya1, and Karen Alim1,21Max Planck Institute for Dynamics and Self-Organization, Göttingen, Germany — 2Technical University of Munich, Germany

Damage is a risk that all kinds of networks are exposed to. This includes overload in power grids as well as the formation of blood clots in brain microvasculature. The occlusion of a single blood vessel in the brain can cause severe tissue damage and cognitive dysfunction. Experiments and simulations have been done in the past to understand the effect of vessel occlusions on brain blood flow and network architecture. Here, we are interested in the morphological adaptation of a network to occlusion induced flow changes. Is it possible that networks reorganise to minimise the damage caused by lack of flow? For this aim, we use the model organism Physarum polycephalum. In the plasmodial stage, the slime mould forms a network of interconnected tubes through which its cytoplasm streams back and fro, driven by peristaltic tube contractions. Previously, morphological changes due to changes in the contraction pattern have been observed. Here, we locally induce stalling of the flow in a tube of the network and analyse the effect of flow changes on network morphology.

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