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BP: Fachverband Biologische Physik
BP 19: Poster VII
BP 19.26: Poster
Dienstag, 17. März 2020, 14:00–16:00, P2/3OG
Modeling meiotic chromosomes - random walk bridges in a confinement — •Tim Klingberg1,2, Meng Wang1,2, Xingyu Zhang1,2, Hui-Shun Kuan1,2, and Vasily Zaburdaev1,2 — 1Friedrich-Alexander-Universität Erlangen-Nürnberg — 2Max-Planck-Zentrum für Physik und Medizin
The alignment and correct pairing of homologous chromosomes is a crucial step during meiosis. In its early stages, the chromosomes are tethered with their telomeres to the nuclear envelope. Telomers may interact with the cytoskeleton while the fluctuations of chromosomes in the nucleus are affected by the physical properties of the chromatin and the state of the nucleoplasm. Overall, it is largely not understood how the homologous chromosomes manage to align and pair with the exquisite precision and in a short period of time. Our goal is to understand physical limitations of the pairing and homologous search process. To this end, we focus on quantifying possible configurations of tethered chromosomes in the confinement of the nucleus. We use the bead-rod polymer model for numerical simulations and the theory of random walk bridges for analytical calculations. We show that a smaller persistence length leads to smaller polymer fluctuations but also to a higher entropic force acting on tethered ends. We argue that such an optimization problem may determine physical properties of chromosomes in meiosis.