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BP: Fachverband Biologische Physik
BP 21: Cell Adhesion and Migration, Multicellular Systems I
BP 21.11: Vortrag
Mittwoch, 18. März 2020, 12:45–13:00, HÜL 386
Characterization of Spider Silk for Elucidating the Reasons Behind its Medical Success in Nerve Regeneration Applications — •Aida Naghilou1, Lena Pöttschacher2, Flavia Millesi1, Anda Mann1, Paul Supper1, Ellen Backus22, and Christine Radtke1 — 1Research Laboratories of the Division of Plastic and Reconstructive Surgery, Medical University of Vienna, Vienna, Austria — 2Department of Physical Chemistry, University of Vienna, Vienna, Austria
Spider silk has been established as a fascinating materials due to its unique strength, toughness, and elasticity [1]. One of the more remarkable applications of the spider silk is its use for nerve growth and nerve regeneration [2]. The Schwann cells, which are a crucial part of the nerve regeneration process, adhere well to spider silk and migrate along it [3]. However, the reasons behind the medical success of the silk is unclear.
In this work, we performed systematic studies for the material characterization and medical performance of various spider silks. The characterization experiments focus on the Raman spectroscopy, morphology, and wettability of the silk. The medical assessment of the silk in evaluated by in vitro experiments with Schwann cells, where the adhesion, motility, and the proliferation of the cells on the spider silk in monitored. [1] L. Römer, T. Scheibel, Prion, 2 (2008) 154. [2] C. Radtke, Int J Mol Sci, 17 (2016) 1754. [3] T. Kornfeld, P.M. Vogt, V. Bucan, C.-T. Peck, K. Reimers, C. Radtke, J Funct Biomater, 7 (2016) 30.