Dresden 2020 – wissenschaftliches Programm
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BP 23.4: Hauptvortrag
Mittwoch, 18. März 2020, 10:30–11:00, ZEU 250
Mechanical signalling in cell fate choice — •Kevin Chalut — Wellcome-MRC Stem Cell Institute, University of Cambridge, Cambridge, UK
Abstract. Mechanical signaling in cell fate choice plays a significant role in tuning stem cell function. Specifically, my lab has shown that mechanics tunes the response of stem cells to biochemical signaling to steer fate choice. The feedback loop between mechanics and biochemical signaling has significant impact on cellular plasticity both in development and stem cells. I will show that, by tuning the mechanical microenvironment, we can reverse the loss of plasticity associated with ageing of stem cells in the brain. I will also show that, in vivo, we can *fool* the stem cells in an aged brain into functioning as if they are in a soft, neonatal-like environment, thereby leading them to function like young stem cells. This result could have significant impact on treatments of disease like multiple sclerosis. I will then explore how cell surface mechanics in general contextualizes signalling to drive cell fate choice, both in embryonic stem cells and in vivo.