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BP: Fachverband Biologische Physik

BP 30: Cell Adhesion and Migration, Multicellular Systemadhesion and Migration, Multicellular Systems II

BP 30.4: Vortrag

Donnerstag, 19. März 2020, 10:30–10:45, HÜL 386

(In-)stability of growing tissue interfaces — •Tobias Büscher, Gerhard Gompper, and Jens Elgeti — Theoretical Soft Matter and Biophysics, Institute of Complex Systems and Institute for Advanced Simulations, Forschungszentrum Jülich, 52425 Jülich, Germany

Interfaces of tissues are ubiquitous, between tissue and environment as well as between populations of different cell types. The propagation of an interface can be driven mechanically, e.g. by a difference in the respective homeostatic stress of the different cell types [1,2]. Computer simulations of growing tissues are employed to study the competition of two tissues on a substrate. In particular, we focus on the stability of the interface between them [3]. Two identical tissues of course mix with time. Even a small difference in tissue properties results in competition and demixing. A stable interface emerges for competition driven by a difference in homeostatic stress. However, it becomes unstable above a critical difference for reduced apoptosis rates of the weaker tissue. A finger-like protrusion remains in the stronger, invading, tissue.

A difference in directed bulk motility also suffices to result in competition and a stable interface between them, even for otherwise identical tissues. Larger differences in motility force however result in a clear finite-wavelength instability of the interface. Interestingly, this instability seems to be bound by higher order terms, such that the amplitude of the undulation only grows to a finite value.

[1] Podewitz et al., 2016, New J. Physics 18, 083020

[2] Ranft et al., 2014, New J. Phys. 16, 035002

[3] Williamson et al., 2018, Phys. Rev. Lett. 121, 238102