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Dresden 2020 – wissenschaftliches Programm

Die DPG-Frühjahrstagung in Dresden musste abgesagt werden! Lesen Sie mehr ...

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BP: Fachverband Biologische Physik

BP 32: Focus Session: Nonlinear Dynamics of the Heart I (joint session DY/BP)

BP 32.5: Vortrag

Donnerstag, 19. März 2020, 10:45–11:00, ZEU 118

Synchronization of viscoelastically coupled cardiomyocytes — •Florian Spreckelsen1,2,3, Stefan Luther1,2,3, and Ulrich Parlitz1,2,3,41Max Planck Institute for Dynamics and Self-organization, Göttingen, Germany — 2University of Göttingen, Institute for the Dynamics of Complex Systems, Göttingen, Germany — 3DZHK (German Center for Cardiovascular Research), Partner Site Göttingen, Germany — 4University Medical Center Göttingen (UMG), Institute of Pharmacology and Toxicology, Göttingen, Germany

Periodically beating cardiomyocytes coupled mechanically by a viscoelastic extracellular matrix are modelled as viscoelastically coupled excitable oscillators. Their synchronization dynamics depends on the stiffness of the coupling matrix [1].

Systems of two coupled cells and linear chains are investigated numerically. At high stiffness of the viscoelastic coupling, full in-phase synchronization is found. Partial n:n synchronization is observed in case of intermediate stiffness. In the special case of purely elastic coupling, two cells show antiphase synchronization while antiphase chimera states are found in linear chains.

The conditions necessary for the synchronization of viscoelastically coupled cardiomyocytes may give a mechanistic explanation for the importance of fibroblasts to the engineering of cardiac tissue [2,3].

[1] Spreckelsen, Luther, Parlitz, Phys. Rev. E 100, 2019

[2] Tiburcy et al., Circulation 135, 2017

[3] Schlick et al., Prog Bio Mol Bio 144, 2019

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