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BP: Fachverband Biologische Physik
BP 34: Nonlinear Dynamics of the Heart II (joint session DY/BP)
BP 34.5: Vortrag
Donnerstag, 19. März 2020, 15:15–15:30, ZEU 118
General equilibrium approach to resolve ventricular calcium homeostais — •Enrique Alvarez-Lacalle1, Blas Echebarria1, Angelina Peñaranda1, Inmaculada R. Cantalapiedra1, Yohannes Shiferaw2, and David Conesa1 — 1Departament de Física. Universitat Politècnica de Catalunya (UPC-BarcelonaTech), Barcelona, Spain. — 2Department of Physics. California State University Nortridge, Los Angeles, USA.
The ventricular contraction in the heart is roughly proportional to the amount of calcium released from the Sarcoplasmic Reticulum during systole. The change in the membrane potential triggers the opening of thousands of Ryanodine Receptor clusters in the SR membrane, being the release larger when pre-systolic calcium levels are larger. While it is rather straightforward to measure calcium levels and contractibility under different physiological conditions, the complexity of calcium handling during systole and diastole has made the prediction of its release at steady-state from measurements away from steady-state impossible. In this contribution, we present a general equilibrium framework to understand how homeostasis can be understood and analyzed to make predictions about its level when key properties of ionic channels or buffers (due to phosphorylation, genetic mutation,etc..) involved in calcium handling are changed. This framework should be useful to describe why different animals have such different homeostatic behavior upon changes in the pacing rate and provide a physiological mechanism for SERCA gene therapy failure.