Dresden 2020 – wissenschaftliches Programm
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BP: Fachverband Biologische Physik
BP 40: Systems Biology, Evolution and Neural Networks II
BP 40.2: Vortrag
Freitag, 20. März 2020, 09:45–10:00, ZEU 250
Multiscale activity in circadian clocks — •Pablo Rojas1, Jenny A. Plath2, Julia Gestrich2, Bharath Ananthasubramaniam3, Hanspeter Herzel3, Monika Stengl2, and Martin E. Garcia1 — 1Theoretical Physics, University of Kassel, Kassel, Germany — 2Animal Physiology, University of Kassel, Kassel, Germany — 3Institute for Theoretical Biology, Humboldt University of Berlin and Charité Universitätsmedizin, Berlin, Germany
The circadian clock orchestrate daily rhythms in physiology, metabolism and behavior. A group of neurons in the brain (the clock) is responsible for this ~24h rhythm. Single neurons in the clock show rhythms with periods ranging from milliseconds (action potential firing) to ~24 hours (circadian expression of clock genes). How cells interact and achieve synchronization in the clock is still a central question. To address this fundamental problem, we performed long term in-vivo electrophysiology (loose-patch clamp) recordings in the cockroach circadian clock. We developed and applied a method, based on wavelets, to detect and analyze electrical events of different timescales, an reduce the complexity of the datasets. We also provide tools for screening and detecting signatures of synchronization and network interaction episodes ranging from minutes to hours, promisingly closing the gap between the fastest and slowest timescales [1]. Our result over experimental datasets are combined with mathematical modeling, in order to describe internal configuration in the clock network.
[1] Rojas, P. et al, Network Neuroscience 2019