Dresden 2020 – wissenschaftliches Programm
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BP 9.6: Poster
Montag, 16. März 2020, 17:30–19:30, P2/2OG
Modeling Interactions of Molecular Motors with Microtubule Lattice — •William Lecompte1, Sarah Triclin2, Laurent Blanchoin2, Manuel Théry3, and Karin John1 — 1Univ. Grenoble-Alpes, CNRS, Laboratoire Interdisciplinaire de Physique, 38000 Grenoble, France — 2Univ. Grenoble-Alpes, CEA, CNRS, INRA, Biosciences & Biotechnology Institute of Grenoble, Laboiratoire de Physiologie Cellulaire & Végétale, CytoMorpho Lab, 38054 Grenoble, France — 3Univ. Paris Diderot, INSERM, CEA, Hôpital Saint Louis, Institut Universitaire d'Hématologie, UMRS1160, CytoMorpho Lab, 75010 Paris, France
Microtubules and their associated molecular motors are ubiquitous in eukaryotic cells. On the one hand, short lived dynamic microtubules are essential for important cellular processes, such as mitotic spindle positioning during mitosis. On the other hand, long lived microtubules are important structural elements, for example as transport tracks for intracellular traffic. Over the past three decades the dynamic instability at the microtubule tip has been the subject of intensive research, however little is known about the dynamics of the microtubule shaft lattice. Recently it has been shown, that structural lattice defects or severing enzymes such as katanin or spastin may trigger a lattice turnover in the shaft. Here we explore with a kinetic Monte Carlo model the possibility, that the lattice strain induced by molecular motors, such as kinesin motors, may induce a localized lattice turnover. We compare our results with recent in vitro experimental observations on lattice turnover triggered by kinesin motors.