Dresden 2020 – wissenschaftliches Programm
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CPP 97.3: Vortrag
Donnerstag, 19. März 2020, 15:45–16:00, ZEU 255
A new polymorph in triglyceride nanoparticles prepared by antisolvent precipitation — •Isabel Schuldes1, Dennis M. Noll1, Klaus Götz1,2, and Tobias Unruh1,2 — 1Institute for Crystallography and Structural Physics, Universitaet Erlangen-Nuernberg, Erlangen, Germany — 2Interdisciplinary Center for Nanostructured Films, Universitaet Erlangen-Nuernberg, Erlangen, Germany
Antisolvent precipitation (AP) is a low-cost bottom-up method for the preparation of nanoparticles, e.g. for pharmaceutical applications. We report small (~ 25 nm in diameter) triglyceride (tripalmitin, trimyristin) nanoparticle dispersions prepared by AP, which exhibit unexpected structural characteristics: differential scanning calorimetry (DSC) and wide-angle X-ray scattering (WAXS) measurements show an uncommon melting behaviour and an untypical crystalline phase. The presence of said untypical phase has been reported in triglyceride nanosuspensions previously, but has not been studied as it represented only a minor fraction of the dispersion . In contrast, we have observed that in dispersions prepared by AP this phase is predominant. Small-angle X-ray and neutron scattering (SAXS, SANS) measurements further revealed an interfacial structure of the liquid triglyceride nanoparticles. Such structure was recently suggested to be a general feature among small nanoparticles prepared by AP  and might play a role in the formation of the observed untypical phase. Our findings may help to tailor triglyceride nanoparticles for application as drug delivery systems.  H. Bunjes et al., Langmuir, 2000, 16, 5234.  I. Schuldes et al., Langmuir, 2019, 35 (42), 13578.