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BP: Fachverband Biologische Physik

BP 24: Poster B: Active Biological Matter, Cell Mechanics, Systems Biology, Computational Biophysics, etc.

BP 24.24: Poster

Dienstag, 23. März 2021, 16:00–18:30, BPp

Calcium Dynamics Model in Endothelial Cells — •Ananta Kumar Nayak¹, Zhe Gou¹, Sovan Lal Das², and Chaouqi Misbah¹ — ¹Univ. Grenoble Alpes, CNRS, LIPhy, Grenoble 38000, France. — ²Department of Mechanical Engineering, Indian Institute of Technology Palakkad, Palakkad 678557, India.

Calcium is a ubiquitous molecule and a second messenger that regulates many cellular functions ranging from the exocytosis to the proliferation of cell. Endothelial cells (ECs) form a inner lining of blood vessels and play an important role in transduction of extracellular environment information to the cytoplasm. A robust calcium dynamics model is required to understand these cellular functions occurring at (patho) physiological conditions in the ECs. In this work, we have developed a single cell minimal calcium dynamics model by including cytosol and endoplasmic reticulum (ER) calcium, Inp3 (Inositol Trisphosphate) kinetics, and the receptor dynamics. We find that the receptor desensitization due to phosphorylation and recycling of receptor play a vital role in maintaining the calcium homeostasis in the presence of a constant stimulus due to adenosine triphosphate (ATP). Apart from this, our model is able to capture other experimental facts like refilling of calcium in ER, which is dependent on the extracellular calcium concentration. Overall the model is able to account for the natural physiological recovery towards homeostasis of active components in the calcium generation cascade. Furthermore, in a future work, we plan to extend this model to include blood flow through the blood vessel to gain insights in the development of vascular diseases.