BPCPPDYSOE21 – wissenschaftliches Programm
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BP: Fachverband Biologische Physik
BP 24: Poster B: Active Biological Matter, Cell Mechanics, Systems Biology, Computational Biophysics, etc.
BP 24.48: Poster
Dienstag, 23. März 2021, 16:00–18:30, BPp
Topology Control and Pruning in Intertwined Biological Flow Networks. — •Felix Kramer1,2 and Carl Modes1,2,3 — 1Max Planck Institute for Molecular Cell Biology and Genetics (MPI-CBG), Dresden 01307, Germany — 2Center for Systems Biology Dresden (CSBD), Dresden 01307, Germany — 3Cluster of Excellence Physics of Life (PoL), Dresden 01062, Germany
Any larger organism is dependent on the proper distribution of supplies such as water, oxygen, nutrients etc, through extended and complex vessel systems. Naturally, the morphogenesis of these vessel networks during their earliest developmental stages has been extensively studied, in particular for slime-molds, leaf venation systems and vessel systems in vertebrates. Interestingly enough there is a universal hypothesis for the onset of maturation of any rudimentary network: Mechanic stresses, caused by the fluid flow, drive the development of the system toward a stationary state representing on optimum of dissipation, flow uniformity or metabolite distribution. Nevertheless, the influence of environmental factors on such long-term adaptation dynamics as well as the networks structure and function have not been fully understood. Therefore, interwoven channel systems such as found in the liver, kidney and pancreas, present a novel challenge and key opportunity regarding the field of coupled distribution networks. We here present an advanced version of the discrete Hu-Cai model, coupling two spatial networks in 3D. We show that spatial coupling of two flow-adapting networks can control the onset of topological complexity in concert with short-term flow fluctuations.