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BP: Fachverband Biologische Physik

BP 24: Poster B: Active Biological Matter, Cell Mechanics, Systems Biology, Computational Biophysics, etc.

BP 24.50: Poster

Tuesday, March 23, 2021, 16:00–18:30, BPp

Morpheus: A user-friendly modeling and simulation framework for multicellular systems — Jörn Starruß, Diego Jahn, Robert Müller, Andreas Deutsch, and •Lutz Brusch — Center for Information Services and High Performance Computing (ZIH), Technische Universität Dresden, Germany

Computational modeling and simulation become increasingly important to analyze tissue morphogenesis. Existing software for multicellular models require scientists to encode their models in an imperative programming language. Morpheus (1,2), on the other hand, is an extensible open-source software framework that is entirely based on declarative modeling. It uses the domain-specific language MorpheusML to define multicellular models through a user-friendly GUI and has since proven applicable by a much broader community, including experimentalists. We here present how MorpheusML enables advanced scientific workflows (3) and cross-software exchange of multicellular models (4). MorpheusML can represent the spatial and mechanical aspects of interacting cells. A numerical simulation is then composed by automatic scheduling of predefined components in the simulator. Moreover, Morpheus supports simulations based on experimental data, e.g. segmented cell configurations, and offers a broad set of analysis tools to extract features right during simulation.

(1) Starruß et al. Bioinformatics 30, 1331, 2014. (2) Morpheus homepage: https://morpheus.gitlab.io (3) Parameter estimation workflow: https://fitmulticell.gitlab.io (4) Model standardization: https://multicellml.org