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BP: Fachverband Biologische Physik
BP 24: Poster B: Active Biological Matter, Cell Mechanics, Systems Biology, Computational Biophysics, etc.
BP 24.51: Poster
Dienstag, 23. März 2021, 16:00–18:30, BPp
Exploring theoretical limits for the lifespan of C.elegans dauer larvae under periodic feeding — •Xingyu Zhang1,2, Sider Penkov3, Damla Kaptan3, Teymuras V. Kurzchalia3, and Vasily Zaburdeav1,2 — 1Friedrich-Alexander-University Erlangen-Nuremberg — 2Max-Planck-Zentrum für Physik und Medizin — 3Max Planck Institute of Molecular Cell Biology and Genetics
Recent finding suggests that the dauer larva of C.elegans may utilize external ethanol as an energy source to extend its lifespan, and a mathematical model was proposed to explain the connection between the lifespan of dauer larva and its ethanol metabolism. To explore possible ways to further extend the lifespan of dauer larva, we inter-operated self-recovery mechanisms which were previously omitted in the previous model. Numerical simulations of the revised model suggest that, if ethanol is supplied periodically with suitable frequency and amplitude, the dauer could survive as long as we observe the system. Analytical methods further explains how the feeding frequency and amplitude affects the lifespan extension. We proposed the range of feeding protocols that can now be tested experimentally.