Regensburg 2022 – wissenschaftliches Programm

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BP: Fachverband Biologische Physik

BP 12: Poster 2

BP 12.2: Poster

Dienstag, 6. September 2022, 17:30–19:30, P4

Heterogenous cell structures in AFM and shear flow simulations — •Sebastian Wohlrab, Sebastian Müller, and Stephan Gekle — Theoretical Physics VI, University of Bayreuth

In biophysical cell mechanics simulations, the complex inner structure of cells is often simplified as homogeneous material. However, this approach neglects individual properties of the cell's components, e.g., the significantly stiffer nucleus.

By introducing a stiff inhomogeneity inside our hyperelastic cell, we investigate it during AFM compression and inside shear flow in finite-element and Lattice Boltzmann calculations.

We show that a heterogenous cell exhibits almost identical deformation behavior under load and in flow as compared to a homogeneous cell with equal averaged stiffness, supporting the validity of the homogeneity assumed in both mechanical characterization as well as numerical computations.