Regensburg 2022 – wissenschaftliches Programm
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BP: Fachverband Biologische Physik
BP 12: Poster 2
BP 12.40: Poster
Dienstag, 6. September 2022, 17:30–19:30, P4
Tissue tension during zebrafish development — •Ming Hong Lui1,2, Alejandro Jurado1, Leon Lettermann1, and Timo Betz1,2 — 13rd Institute of Physics - Biophysics, University of Göttingen, Friedrich-Hund-Platz 1, 37077 Göttingen — 2Max Planck School Matter to Life
Understanding the morphogenesis during development is one of the emerging fields where the interaction between developmental and tissue biology with biophysics has provided a series of deep new insights into natures physical working principles. In particular, during embryonic development of zebrafish, cells in the blastoderm exhibit collective migration towards the yolk in a process known as epiboly, as well as the subsequent gastrulation that involves symmetry breaking. These elegantly robust processes are facilitated by both biochemical and mechanical interactions. To determine how tissue stresses contribute mechanically we use photoablation to create mechanical defects in the tissue and record the subsequent tension relaxation using light sheet microscopy of the whole embryonic volume. We analyze and contrast the nuclei trajectories, density, velocity and force maps with and without the ablative perturbation. From the changes in these quantities, we can infer the adaptive response of the embryo, the source of force generation, and the role played by tissue tension in guiding the coordinated movement.