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BP: Fachverband Biologische Physik

BP 12: Poster 2

BP 12.58: Poster

Tuesday, September 6, 2022, 17:30–19:30, P4

Protein Dynamics in the Complex Physical Environment of the Synapse — •Simon Dannenberg, Sarah Mohammadinejad, and Stefan Klumpp — Institut für Dynamik komplexer Systeme Georg-August-Universität Göttingen, Göttingen, Germany

The synapse is a complex environment that is densely packed with proteins and has an internal geometry structured by membranes. This affects the mobility of proteins involved in signal transmission and hence, their availability at corresponding reaction sides.

In our work we use dynamic Monte Carlo simulations to investigate the individual influences of different physical features of the synapse on protein mobility. The simulations are parameterized by mobility measurements via FRAP experiments. By simulating protein mobility in synapses with different geometric features such as synapse volume and vesicle number, we study the influence of these features on concentration profiles in the synapse and other key aspects of signal transmission.