Regensburg 2022 – wissenschaftliches Programm

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BP: Fachverband Biologische Physik

BP 15: Protein Structure and Single Molecules

BP 15.7: Vortrag

Mittwoch, 7. September 2022, 12:00–12:15, H13

Understanding friction in ligand protein systems — •Miriam Jäger¹, Wanhao Cai², Jakob T. Bullerjahn³, Thorsten Hugel², Steffen Wolf¹, and Bizan N. Balzer² — ¹Biomolecular Dynamics, Institute of Physics, University of Freiburg, Hermann-Herder-Str. 3, 79104 Freiburg, Germany — ²Institute of Physical Chemistry, University of Freiburg, Albertstr. 21, 79104 Freiburg, Germany — ³Department of Theoretical Biophysics, Max Planck Institute of Biophysics, 60438 Frankfurt am Main, Germany

Both experiments and simulations have shown the importance of friction in biomolecular system dynamics. To gain a deeper understanding of the connection between directional forces and friction, we study the streptavidin-biotin complex in a combination of stereographic force spectroscopy experiments and biased molecular dynamics simulations. While experiments show an increasing mean rupture force and rupture force variance with steeper pulling angles, the simulations display similar internal friction, but an anisotropy in the free energy barriers. Based on the simulation results, we propose that this anisotropy in barriers manifests itself in experiments as the increase in friction. This effect can be viewed as anisotropic friction.