Regensburg 2022 – wissenschaftliches Programm

Bereiche | Tage | Auswahl | Suche | Aktualisierungen | Downloads | Hilfe

BP: Fachverband Biologische Physik

BP 2: Computational Biophysics and Neuroscience

BP 2.2: Vortrag

Montag, 5. September 2022, 09:45–10:00, H13

Membrane-mediated interactions between non-spherical elastic particles — •Jiarul Midya, Thorsten Auth, and Gerhard Gompper — Theoretical Physics of Living Matter (IBI-5/IAS-2), Forschungszentrum Jülich, D-52425 Jülich,Germany

Transport of particles across lipid-bilayer membranes is important for biological cells to exchange information and material with the environment. Large particles often get wrapped by membranes [1]. However, many particles in vivo and in vitro are deformable, e.g., vesicles, filamentous viruses, macromolecular condensates, polymer-grafted nanoparticles, and microgels. Vesicles may serve as a generic model system for deformable particles [2]. Using the Helfrich Hamiltonian, triangulated membranes, and energy minimization, we predict the interplay of vesicle shapes and wrapping states. Increasing particle softness enhances the stability of shallow-wrapped and deep-wrapped states over non-wrapped and complete-wrapped states. The free membrane mediates an interaction between partial-wrapped vesicles. For the deep-wrapped vesicles, we predict a purely repulsive interaction. For shallow-wrapped states, interaction potential depends on the mutual orientation of the vesicles. Our predictions may guide the design and fabrication of deformable particles for efficient use in medical applications, such as targeted drug delivery.
[1] S. Dasgupta et al., J. Phys.: Condens. Matter 29, 373003 (2017); [2] X. Yi et al., Phys. Rev. Lett. 107, 098101 (2011).