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Regensburg 2022 – wissenschaftliches Programm

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BP: Fachverband Biologische Physik

BP 20: Active Matter 4 (joint session DY/BP/CPP)

BP 20.9: Vortrag

Mittwoch, 7. September 2022, 17:15–17:30, H18

Non-equilibrium phase separation in mixtures of catalytically active particles: size dispersity and screening effects — •Vincent Ouazan-Reboul1, Jaime Agudo-Canalejo1, and Ramin Golestanian1,21Max Planck Institute for Dynamics and Self-Organization, Am Fassberg 17, D-37077, Göttingen, Germany — 2Rudolf Peierls Centre for Theoretical Physics, University of Oxford, OX1 3PU, Oxford, UK

Biomolecular condensates in cells are often rich in catalytically active enzymes. This is particularly true in the case of the large enzymatic complexes known as metabolons, which contain different enzymes that participate in the same catalytic pathway. One possible explanation for this self-organization is the combination of the catalytic activity of the enzymes and a chemotactic response to gradients of their substrate, which leads to a substrate-mediated effective interaction between enzymes. These interactions constitute a purely non-equilibrium effect and show exotic features such as non-reciprocity. Here, we analytically study a model describing the phase separation of a mixture of such catalytically active particles. We show that a Michaelis-Menten-like dependence of the particles' activities manifests itself as a screening of the interactions, and that a mixture of two differently sized active species can exhibit phase separation with transient oscillations. We also derive a rich stability phase diagram for a mixture of two species with both concentration-dependent activity and size dispersity.

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