Regensburg 2022 – wissenschaftliches Programm
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BP: Fachverband Biologische Physik
BP 22: Migration and Multicellular Systems
BP 22.9: Vortrag
Donnerstag, 8. September 2022, 12:00–12:15, H15
On multistability and constitutive relations of cell motion on Fibronectin lanes — Behnam Amiri1, •Johannes Clemens Julius Heyn2, Joachim Oskar Rädler2, and Martin Falcke1,3 — 1Max Delbrück Center for Molecular Medicine in the Helmholtz Association, Robert Rössle Str. 10, 13125 Berlin, Germany — 2Ludwig-Maximilians-Universität München (LMU), Fakultät für Physik, Geschwister-Scholl-Platz 1, 80539 München, Germany — 3Dept. of Physics, Humboldt University, Newtonstr. 15, 12489 Berlin, Germany
Migration of eukaryotic cells is a fundamental process for embryonic development, wound healing, immune responses, and tumour metastasis. Many cell types exhibit coexisting steady and oscillatory morphodynamics on flat substrates. There is, however, little quantitative understanding of how adhesion controls these dynamic states.
We study the motion of MDA-MB-231 cells on microlanes of a broad range of Fibronectin densities to address this topic and derive a biophysical model.
The experiments exhibit cells with steady or oscillatory morphodynamics and either spread or moving with spontaneous transitions between the dynamic states. Our biophysical model is based on the force balance at the protrusion edge, the noisy clutch of retrograde flow and a response function of friction and membrane drag to integrin signaling. The theory reproduces the experimentally observed cell states, characteristics of oscillations and state probabilities.