Regensburg 2022 – wissenschaftliches Programm
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BP: Fachverband Biologische Physik
BP 25: Bioinspired Systems
BP 25.4: Vortrag
Donnerstag, 8. September 2022, 11:45–12:00, H13
Memory effect of red blood cells in a 3D microfluidic chip — •Amirreza Gholivand1,2 and Minne Paul Lettinga1,2 — 1Forschungszentrum Jülich, IBI-4, Jülich, Germany — 2KU Leuven, Laboratory of Soft Matter and Biophysics, Leuven, Belgium
The significance of healthy blood vessels and blood flow for proper brain functioning is becoming more recognized, for example due to its involvement in the development of human neurodegenerative disorders, notably Alzheimer's disease. Therefore, it is of interest to develop a platform to investigate blood flow and blood cell behavior through the brain vasculature.
Here we present model 3-D microfluidic channels to study the RBCs flow through different vessels geometry and their flow dynamics. RBCs in microcirculation and at bifurcation may attain different memory effect, which we studied systematically varying the interaction strength between the red blood cells and the complexity of flow geometries. To this end, we make use of a novel technique, Selective Laser-induced Etching (SLE), which can produce 3D structures in glass with any desirable shape. To study the shape memory of the vessels the second generation of the bifurcation has been implemented with a parallel and perpendicular orientation relative to the first bifurcation. Using ultra-fast microscopy in combination with velocimetric analysis, we identify a new memory effect, where there is a shift in the maximum velocity, depending on the orientation of the downstream bifurcation.