Regensburg 2022 – wissenschaftliches Programm
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BP: Fachverband Biologische Physik
BP 8: Focus Session: Phase Separation in Biochemical Systems
BP 8.7: Vortrag
Dienstag, 6. September 2022, 11:30–11:45, H15
Catalysis-Induced Phase Separation and Autoregulation of Enzymatic Activity — Matthew W. Cotton1,2, Ramin Golestanian2,3, and •Jaime Agudo-Canalejo2,4 — 1Mathematical Institute, University of Oxford, Oxford, United Kingdom — 2Department of Living Matter Physics, Max Planck Institute for Dynamics and Self-Organization, Göttingen, Germany — 3Rudolf Peierls Centre for Theoretical Physics, University of Oxford, Oxford, United Kingdom — 4Institute for Theoretical Physics, University of Heidelberg, Heidelberg, Germany
Studying the effect of non-equilibrium activity on intracellular phase separation is a very active research area, but all previous studies have still relied on equilibrium interactions as the driver for phase separation. Here, we present a thermodynamically consistent model describing the dynamics of a multi-component mixture where one enzyme component catalyzes a reaction between other components. We find that the catalytic activity alone can induce phase separation for sufficiently active systems and large enzymes, without any equilibrium interactions between components [1]. In the limit of fast reaction rates, binodal lines can be calculated using a mapping to an effective free energy. We also explain how this catalysis-induced phase separation (CIPS) can act to autoregulate the enzymatic activity, which points at the biological relevance of this phenomenon.
[1] M. W. Cotton, R. Golestanian, and J. Agudo-Canalejo, arXiv:2205.12306 (2022).