Regensburg 2022 – wissenschaftliches Programm
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CPP: Fachverband Chemische Physik und Polymerphysik
CPP 45: Biopolymers, Biomaterials and Bioinspired Functional Materials (joint session CPP/BP)
CPP 45.4: Vortrag
Freitag, 9. September 2022, 10:30–10:45, H39
Anionically functionalized glycogens efficiently encapsulate cationic peptides — Hanna Zhukouskaya1, •Pablo M. Blanco2, Zulfiya Černochová1, Lucie Čtveráčková1, Roman Staňo3, Ewa Pavlova1, Miroslav Vetrík1, Peter Černoch1, Miroslav Šlouf1, Marcela Filipová1, Miroslav Štěpánek2, Martin Hrubý1, Peter Košovan2, and Jiří Pánek1 — 1Institute of Macromolecular Chemistry, Czech Academy of Sciences, Heyrovského nám. 2, 162 06 Prague 6, Czech Republic — 2Department of Physical and Macromolecular Chemistry, Faculty of Science, Charles University, Hlavova 8, 128 40 Prague 2, Czech Republic — 3Faculty of Physics, University of Vienna, Kolingasse 14-16, 1090 Vienna, Austria
We developed and tested novel acid-functionalized glycogen conjugates as supramolecular carriers for efficient encapsulation and inhibition of a model cationic peptide melittin, which is the main component of honeybee venom. Systematic investigation of this model system allowed us not only to test its potential application as honeybee venom antidote but also to assess the role of the degree of substitution and solution pH in the interactions of these anionic carriers with multivalent cationic cargos. Our results demonstrate that the concept of electrostatically driven encapsulation by acid-functionalized glycogens should be applicable not only to the model case of melittin but also to other multivalent cationic biomolecules.