Regensburg 2022 – wissenschaftliches Programm
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CPP: Fachverband Chemische Physik und Polymerphysik
CPP 5: Wetting, Droplets and Microfluidics (joint session DY/CPP)
CPP 5.9: Vortrag
Montag, 5. September 2022, 12:15–12:30, H19
Imaging, Analysis and Sorting in Microfluidic Systems: Correlative Multi-Contrast, Multi-Parameter Applications — •Tobias Neckernuss1, Patricia Schwilling2, Jonas Pfeil1,2, Daniel Geiger1, and Othmar Marti2 — 1Sensific GmbH — 2Institute for Experimental Physics, Ulm Univeristy
Droplet-based microfluidics is a promising approach in biology, pharmacy, medicine, and lab-on-a-chip applications. One remaining problem is the lack of a suitable fast image-based detection method that enables droplet- and content-based analysis and sorting with rates fast enough to be sufficient for high-throughput measurements and to enable surveilled lab scale production. We demonstrate recent advances for high-speed, real-time, image-based analysis and manipulation of microfluidic systems. With rates of up to 3000 particles or droplets per second we show applications of our system in the field of droplet-based microfluidics. Here, we concentrate on droplet-content analysis and have a sneak look at further potential applications in biology and image-based cell analysis. We introduce new contrast types for image-based analysis like brightfield, darkfield, phase contrast, fluorescence and combinations thereof. Combining new cutting edge hardware technology with specifically tailored software and integration of external lab infrastructure enables us reach new dimensions in image based particle analysis and sorting.