Regensburg 2022 – wissenschaftliches Programm
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SOE: Fachverband Physik sozio-ökonomischer Systeme
SOE 20: Nonlinear Dynamics 2: Stochastic and Complex Systems, Networks (joint session DY/SOE)
SOE 20.3: Vortrag
Freitag, 9. September 2022, 12:00–12:15, H19
ANDOR and beyond: Dynamically switchable logic gates as modules for flexible information processing in biochemical regulatory networks — •Mohammadreza Bahadorian1,2 and Carl D. Modes1,2,3 — 1Max Planck Institut for Molecular Cell Biology and Genetics (MPI-CBG), 01307 Dresden, Germany — 2Center for Systems Biology Dresden (CSBD), 01307 Dresden, Germany — 3Cluster of Excellence Physics of Life, TU Dresden, 01069 Dresden, Germany
Understanding how complex (bio-)chemical regulatory networks may be capable of processing information in flexible, yet robust ways is a key question with implications in biology and dynamical systems theory. Considerable effort has been focused on identification and characterization of structural and dynamical motifs of biological information processing, but a framework for studying flexibility and robustness of the motifs is lacking. We here propose a small set of effective modules capable of performing different logical operations based on the basin of attraction in which the system resides. These dynamically switchable logic gates require fewer components than their traditional analogs where static, separate gates are used for each desired function. We demonstrate the applicability and limits of these circuits by determining a robust range of parameters over which they correctly operate and then characterize their resilience against intrinsic noise of the constituent reactions using the theory of large deviations. Trade-offs between multi-functionality and robustness against various types of noise are shown.