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ST: Fachverband Strahlen- und Medizinphysik

ST 9: Radiation Therapy

ST 9.2: Talk

Thursday, March 23, 2023, 16:05–16:20, ZEU/0146

Simulations of a combination of brachytherapy and X-ray irradiation for the treatment of intraocular tumors — •Michelle Stroth¹, Henning Manke¹, Dirk Flühs², Bernhard Spaan¹, and Johannes Albrecht¹ — ¹TU Dortmund University, Dortmund, Germany — ²Department of Radiotherapy, Essen University Hospital, Germany

Brachytherapy with Ruthenium-106 Eye Applicators is an effective method for successfully treating ocular tumours. However, this treatment is contraindicated for intraocular tumours with an apex height above 7 mm due to insufficient irradiation of the tumor apex. To reduce side effects that can occur with alternative forms of therapy, an integrated concept consisting of brachytherapy with external X-ray irradiation is investigated for treating intraocular tumours.
For this purpose, the combined therapy modality is simulated using real patient data. The radiation sources’ weights are adjusted by optimization through differential evolution, minimizing the dose to the organs at risk. Comparison of the dose-volume histograms of the combined form of therapy with the dose-volume histograms of brachytherapy only, confirms the advantages of integrating external X-ray irradiation using the ruthenium-106 applicator in terms of protection of the structures at risk and homogeneity of the dose profile in the tumour.
This presentation shows the results of the Monte Carlo simulations of the combined concept.