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ST: Fachverband Strahlen- und Medizinphysik
ST 9: Radiation Therapy
ST 9.6: Talk
Thursday, March 23, 2023, 17:05–17:20, ZEU/0146
Sub-Millimeter Relative Range Verification in Heavy-Ion Therapy using Filtered Interaction Vertex Imaging — •Devin Hymers1,2, Eva Kasanda2, Vinzenz Bildstein2, Joelle Easter2, Andrea Richard3,4, Artemis Spyrou3, Cornelia Hoehr5, and Dennis Muecher1,2,5 — 1Institut für Kernphysik, Universität zu Köln, Köln, Germany — 2Department of Phyiscs, University of Guelph, Guelph, ON, Canada — 3National Superconducting Cyclotron Laboratory, Michigan State University, East Lansing, MI, USA — 4Lawrence Livermore National Laboratory, Livermore, CA, USA — 5TRIUMF, Vancouver, BC, Canada
The growing societal burden of cancer necessitates improvement in safety and efficacy of radiation therapy. Scanned heavy-ion therapy provides precise and highly conformal dose delivery, but inherent uncertainties make it difficult to ensure accuracy. Relative range verification via filtered Interaction Vertex Imaging could allow monitoring of beam depth spacing, to ensure full and consistent tumour coverage. To validate this method, twelve 16O beams of differing energy irradiated a 40 mm poly-(methyl methacrylate) phantom, and external secondary particle yields were monitored with position-sensitive silicon detectors. These data were used to reconstruct sites of secondary particle origin. Comparison of logistic fits to the distal edges of these distributions via χ2 minimization computed the range shift between any two beam depths with sub-millimeter precision, to a standard deviation of the mean of 220(10) µm. This result validates filtered Interaction Vertex Imaging as a candidate for high-performance clinical range verification.