Regensburg 2007 – wissenschaftliches Programm

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CPP: Fachverband Chemische Physik und Polymerphysik

CPP 20: POSTER: Biological Systems + New Materials

CPP 20.1: Poster

Mittwoch, 28. März 2007, 16:00–18:30, Poster B

High Frequency Quartz Crystal Microbalance Flow Cell with Enhanced Accuracy for Liquid and Biochemical Sensing — •Paula Sagmeister, Ingrid Graz, and Reinhard Schwödiauer — Soft Matter Physics, J. Kepler Universität, Altenbergerstraße 69, 4040 Linz, Österreich

Throughout the last twenty years, acoustic wave sensors have been proven as extremely sensitive and accurate devices for a wide variety of physical, chemical and biochemical sensing applications. Systems based on thickness sheer mode (TSM) quartz resonators, working in a liquid environment with resonance frequencies between 5 and 15 MHz, are already established (and commercially available) for real-time measurements of biochemical interactions. The utilisation of high frequency fundamental (HFF) quartz resonators, with resonance frequencies up to 150 MHz (and beyond), could further improve the sensitivity of such systems by orders of magnitude. We present a fully biocompatible flow cell, designed for HFF quartz resonators which, in spite of their small size, can be removed and exchanged quickly and with ease. The system performance is evaluated and quantified by a number of experiments including various viscosity measurement of diluted sugar solutions, the detection of a bovine serum albumin (BSA) monolayer and other biochemical reactions. We further address some specific problems especially related to reusability and cleaning procedures.