Regensburg 2010 – wissenschaftliches Programm
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BP: Fachverband Biologische Physik
BP 31: Posters: Membranes and Vesicles
BP 31.3: Poster
Donnerstag, 25. März 2010, 17:15–20:00, Poster B1
Oscillations in the lateral pressure of lipid monolayers induced by the second messengers MARCKS and Protein Kinase C — •Sergio Alonso1, Markus Bär1, Undine Dietrich2, and Josef A. Käs2 — 1Physikalisch-Technische Bundesanstalt, Berlin, Germany — 2University of Leipzig, Leipzig, Germany
The binding dynamics of the peptide MARCKS to the lipid PIP2 modulated by protein kinase C leads to damped oscillations in lateral pressure of a lipid monolayer. These periodic dynamics can be attributed to changes in the crystalline lipid domain size. We elaborate a mathematical model to explain the observations based on the changes in the physical structure of the monolayer by the translocation of MARCKS peptides. The model equations are numerically integrated and reproduce the experimental observations.