Regensburg 2013 – wissenschaftliches Programm

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BP: Fachverband Biologische Physik

BP 11: Posters: Statistical Physics in Biological Systems (joint with DY)

BP 11.10: Poster

Montag, 11. März 2013, 17:30–19:30, Poster B2

Stochastic tug-of-war model with symmetric motor properties does not provide processive cargo movement. — •Sarah Klein¹, Cecile Appert-Rolland², and Ludger Santen¹ — ¹Theoretische Physik, Universität des Saarlandes, 66123 Saarbrücken — ²Laboratory of Theoretical Physics, Paris-Sud University, Orsay

Many different types of cellular cargos are transported bidirectionally along microtubules by teams of molecular motors. The motion of this object has been experimentally characterized in vivo as processive with rather persistent directionality. By means of an effective theoretical approach, introduced by Lipowsky et al. [1], it has been argued that the dynamics of these object are the result of a tug-of-war between different kinds of motors. This picture has been questioned in a recent article by Kunwar et al. [2], who considered the coupling between motor and cargo in more detail. In this contribution we discuss possible scenarios within this framework that eventually lead to the observed dynamic patterns of bidirectional cargo transport.
[1] M. J. I. Müller, S. Klumpp, R. Lipowsky, PNAS 105, 4609 - 4614 (2008)
[2] A. Kunwar, S. K. Tripathy, J. Xu, PNAS 108(47), 18960-18965 (2011)