Regensburg 2013 – wissenschaftliches Programm
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BP: Fachverband Biologische Physik
BP 11: Posters: Statistical Physics in Biological Systems (joint with DY)
BP 11.14: Poster
Montag, 11. März 2013, 17:30–19:30, Poster B2
Hybrid simulation model for spatiotemporal intracellular calcium signals — •Martin Rückl1, Nagaiah Chamakuri2, and Sten Rüdiger1 — 1Humboldt-Universität, Berlin — 2RICAM, Linz, Austria
Calcium induced calcium release (CICR) from IP3R channels on the ER membrane and the interplay with calcium buffers can result in complex spatiotemporal calcium distributions in the cytosol which play an important role in intra- and extracellular signaling.
To model those patterns, we solve the coupled reaction diffusion and master equations for both the DeYoung-Keizer [1] and the four state [2] stochastic IP3R gating models, using an interplay between a 3D finite element method and the Gillespie algorithm. We investigate the impact of the local calcium decay after a channel closing and the diffusive coupling of clustered channels on the collective stochastic behaviour of the channels. To obtain different calcium decays we performed simulations for different buffer configurations while the diffusive coupling is altered by means of a larger inter channel distance within a channel cluster. Our results can also be used to assess the reliability of different computationally cheaper approximations frequently used in other works.
[1] D.W. DeYoung and J. Keizer, Proc. Natl. Acad. Sci. U.S.A 89, 9895 (1992).
[2] G. Ullah, I. Parker, D.D. Mak, J.E. Pearson, Cell Calcium, 52(2):152-160, 2012