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Regensburg 2013 – wissenschaftliches Programm

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BP: Fachverband Biologische Physik

BP 11: Posters: Statistical Physics in Biological Systems (joint with DY)

BP 11.23: Poster

Montag, 11. März 2013, 17:30–19:30, Poster B2

Limitations on entrainment frequency in cortical slow wave stimulation — •Arne Weigenand1, Lisa Marshall2, Thomas Martinetz1, and Jens Christian Claussen11INB, University of Lübeck — 2Neuroendocrinology, University of Lübeck, Germany

Stimulation of cortical slow waves during sleep has recently raised considerable attention due to enhancement of memory consolidation [1]. We consider the question how slow waves, comprised by bursty up and quiescent down states, can be entrained or strengthened by external stimulation. In a purely cortical model no limitation within the relevant frequency range occurs [2]. Stimulation by TMS or optogenetic methods [3,4] hint at an upper entrainment frequency of 4 Hz. In contrast, our optical stimulation experiments [5] revealed that entrainment is only possible up to 1 Hz. We account thalamic gating for this difference. Hence we consider the inclusion of thalamic feedback loops into generic cortical network models, for adaptation of parameters in a phenomenological mean-field model. We optimize pulse length and frequency to obtain an optimized stimulation protocol.
[1] L. Marshall et al, Nature 444, 610 (2006). [2] Weigenand, Martinetz, Claussen, Cogn. Neurodyn. 6, 367 (2012); Schütt, Claussen, Cogn. Neurodyn. 6, 343 (2012). [3] Massimini et al., PNAS 104, 8407 (2007). [4] Kuki et al, Frequency-dependent entrainment of neocortical slow oscillation to repeated optogenetic stimulation in the anesthetized rat, Neurosci. Res. (2012, in press). [5] Weigenand et al (in preparation).

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