Dresden 2020 – wissenschaftliches Programm

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BP: Fachverband Biologische Physik

BP 9: Poster II

BP 9.21: Poster

Montag, 16. März 2020, 17:30–19:30, P2/2OG

Cooperativity among multiple types of receptor-ligand bonds in membrane adhesion — •Long Li1,2 and Ana-Sunčana Smith1,31PULS Group, Institute for Theoretical Physics, FAU Erlangen-Nürnberg, Erlangen 91058, Germany — 2Key Laboratory of Mechanics on Disaster and Environment in Western China, Ministry of Education, College of Civil Engineering and Mechanics, Lanzhou University, Lanzhou, Gansu 730000, China — 3Division of Physical Chemistry, Ruder Bošković Institute, Bijenička 54, Zagreb 10000, Croatia

In biological system, receptor-ligand bonds rarely work alone and are often embedded into larger macromolecular structures involving more than one pair type. However, the effect of multiple types of receptor-ligand bonds on formation dynamics of adhesion domain is still elusive. We combine theoretical modelling and effective Monte Carlo simulations to investigate the nucleation dynamics of adhesion domains. Typically we find that in during pre-nucleating one or both types of bonds may transiently appear, in the bulk of the parameter space, only one bond type will appear in the stable nucleus of the adhesion domain. The other pair, on the other hand, has catalytic or anti-catalytic effects on the nucleating adhesions. These results not only shed light on the biophysical mechanism of cooperativity between multiple types of bonds in membrane adhesion and but also are interesting in the context of complex functionalisation of functional interfaces in biomedical engineering.

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