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CPP: Fachverband Chemische Physik und Polymerphysik
CPP 47: Focus: Phase Separation in Biological Systems II (joint session BP/CPP)
CPP 47.3: Vortrag
Dienstag, 17. März 2020, 10:00–10:15, ZEU 250
Phase separation provides a mechanism to reduce noise in cells — •Florian Oltsch1,2, Adam Klosin1, Tyler Harmon1,3, Alf Honigmann1,4, Frank Jülicher2,3,4, Anthony Hyman1,2,4, and Christoph Zechner1,2,4 — 1Max Planck Institute of Molecular Cell Biology and Genetics, 01307 Dresden, Germany — 2Center for Systems Biology Dresden, 01307 Dresden, Germany — 3Max Planck Institute for the Physics of Complex Systems, 01187 Dresden, Germany — 4Cluster of Excellence Physics of Life, TU Dresden, 01062 Dresden, Germany
Noise in gene expression can cause significant variability in protein concentration. How cells buffer variation in protein concentration is an important question in biology. In this talk, I will show that liquid-liquid phase separation provides an effective mechanism to reduce variability in protein concentration. First, I will introduce our theoretical framework that discusses phase separation in the presence of active protein production and turnover. This stochastic non-equilibrium model allows us to study how fluctuations in protein concentration are affected by phase separation. I will then present under which physical conditions noise buffering by phase separation can be effective. Subsequently, I will show experimental data to test our theoretical predictions.